Sealed systems never "unload" the driver; the box always provides some resistance. At and below the port tuning frequency, the driver is essentially "unloaded" and just flaps in the wind, leading to high distortion and that infamous "chuffing" noise you can get from ported speakers. A proper design will have a large and smooth enough port to avoid chuffing, and filter to prevent or control undesired low-frequency signals. A ported design's output drops off rapidly below the port tuning frequency; a sealed system drops more slowly. That means in a sealed room you can generally achieve deeper response due to "room gain" reinforcing the subwoofer's output below the -3 dB point -- it will play deeper in a closed room than a ported system with the same -3 dB point. The constant loading also generally means a sealed design will have lower distortion and better time response. But, ported designs generally have higher output, since the port contributes to the output as well as the driver, so more output with less power means potentially lower distortion since less power and driver excursion is required. But the box is generally significantly larger to provide the same LF corner as a sealed system.
Rythmik and other designs with a servo circuit can better control the driver, ported or sealed, so distortion can be comparable between the two. Then it comes down to aesthetics (size) and in-room response desired. I chose sealed for the smaller size, slightly better performance (probably inaudible but what the heck), and additional room gain. In my modest sealed room I gained about an octave, so my in-room -3 dB point is about 7 Hz instead of the sub's native 14 Hz.
Having ported mains or not should not matter if you are rolling off their response well above the port tuning frequency. That is what I recommend, along with real experts like Dr. Toole, but again that comes down to preference and the characteristics of your speakers, room, etc.
HTH - Don