Agree, the slam element I was referring two was that 2 x 12" should move enough air (at the mid-bass frequencies you mentioned) compared to my current 18" (226 sq in is basically equal to 254 sq in) whereas even a single 15" (177 sq in) probably wouldn't cut it in 4,100 cu ft.
I agree on the settings, as well. I will experiment in my room (verified by REW) to see what I need to get the best low distortion & audible low end and also avoid rattling cabinet drawers/windows, etc. Might decide on two different settings for regular listening and party-level SPL.