As far I remember from university, acoustic simulations are still far from perfect. They are only accurate for stochastic and geometric model. Frequencies under Schroeder Frequency, which includes wave theory model and X area are not considered. That means in typical, small domestic rooms (0.8-1.2s reverberation time and 20-30 m^2 area) everything under 200 - 400 Hz is not really modeled.
AFMG EASE and Odeon are two main choices. This software is really expensive - thousands of euros for one license. Definitely not accessible for hobbyists.
I heard there are some simulators only for bass frequencies based at wave theory but I don't have any experience with it.
Some speaker manufacturers, often free of charge offers their own simulation software. This is however usually targeted for line arrays or other professional applications and don't include other manufacturers speaker models.
All in all I don't think it is really possible for hobbyist to simulate acoustics and speakers in domestic applications.