Doing this well just takes some experimenting, and lowered expectations. And it is VERY room dependent.
In very small rooms (bathroom) a single powered speaker is likely the best option.
For general area listening, I have gone with setting them up as close to the "proper" location as possible, and point them close to but not exactly straight into the room. Then go for more of a "wall of sound" approach with small adjustments, meaning instrument locations are in the right place, but they overlap somewhat, have "fuzzy" edges. So my goal will be to be able to walk through the room and hear the musicians on one end, and walking across the room sounds like walking across the back of the venue for a live performance.
So no weird shifts in center/left/right location as I move through the room.
I've had luck with asymetrical speaker placement, where the speakers are shifted to one side of the room, one pointed to the middle, and one pointed to the side just enough to bring enough sidewall reflections to balance out the center toe of the other speaker But this really worked well because they were pointed at a part of the room that vented sound, in a normal sealed room it would be a bad idea.
Ceiling/wall and pointed down is a good way to go, imo. You can space them well, and downward (if done right) can lower reflections. While a corner placement can work, I think you are better off being 1/3 of the wall down from the top of the wall. And on one wall, not right in the corner.