FTR, on a Win10 machine with the latest driver, I get flawless playback over USB. I can switch from all fromats without popping, clicking, or delays. Very happy with the overall performance.
Where I run into issues is with an old Squeezebox Touch using a plugin to stream high rez digital across the USB. Then, I will get and initial pop when switching from 44.1 to DSF. Once the tracks start palying there is no pop, just when the switching occurs. I believe it is a driver issue and possibly Linux related. My solution is to not use the DO100 with the Touch but instead use the Topping E50 which is flawlless.
I have not tried the the other digital inputs on the DO100 so can't comment.