Low gain.
Then set the volume to the maximum that you are gonna use instead of 100%.
If 100% at low gain is not enough then use high gain.
Well in a listening session I might listen to classical and jazz and then rock and EDM, so the dynamic range of the mastering can vary wildly.
I know about replaygain, but I have never really bothered to use that. Wonder if that would not be a bad idea either. But would replaygain boost the level of my really quiet classical music? Is a digital boost like that even safe from clipping or distortion?
Another reason for why I need higher volume than most is because I am using a Harman PEQ (oratory1990) for my HD800 which requires a -7.7dB preamp gain in order to prevent any frequency boosting/clipping
Occasionally even 100% low gain is not quite enough volume for my liking with some really quietly mastered tracks, but I think 100% low gain is enough for about 90% or more of my content at least.
But would you think that the downside of high gain would really be noticeable or is it likely a largely inaudible difference?