In a perfect world, you would determine the optimal output from your pre-outs, and then adjust the gain so you get the lowest possible THD+N, while still having full output available...I have my xls 1502 at home and it works great (so far no hiss issues, it works just fine)
How should I set the gain regulators at both sides of the screen? I have them at 25% of their total capacity, is that ok_
In the real world, I set it to around 75% and be done with it - I have no hiss.
If you have access to a review of your pre, where the pre-out was measured for SINAD or THD+N at different levels - you will be able to see where the performance is best - and whether you should aim for high gain (turn down the pre) or low gain (turn up the pre)
Also mine is first generation, on the second generation models like yours, you also have an option for consumer vs pro sensitivity (high gain vs low gain) and the gain dial then works on top of that.