Been looking at this for a few days. Problem is that to use it fully with digital inputs I would have to forego surround - as is I'm EQ:ing on my PC and the results are very nice, but of course I can't apply that to my TV's internal apps - since Windows doesn't give 4K and the rest of that good stuff with streaming other than maybe Netflix - or my PlayStations. And while I'm not the pickiest person by any measure, so many finding faults in the sound quality is admittedly a concern since I can't test without buying.
The Flex seems to have less detractors - though then again it's a lot newer product with less users - but the price jumps from ~250€ for the 2x4 HD to 800€ for the Flex in Europe! Doesn't seem there's a version without Dirac here. Not that Dirac would be bad in itself, but when without it the Flex would likely be around 550€ I'm not sure if 250€ for Dirac would even make sense when you can just do the EQ manually with REW and UMIK-1. Plus the total cost of 800€ is very much "oof" since I even started looking at the 2x4 HD as a budget alternative to - or rather to tide me over until - a new AVR for which I'd probably need something like X3700H at 1500€ to get reasonable EQ and also more than two height channels. And while 800€ is less than 1500€, when you factor in losing surround it's just... nope, not gonna happen.
Technically I could still use the 2x4 HD (or regular 2x4, but it's not as good?) with my current surround setup if I use the pre-outs on my AVR to connect my stereo amp for the front speakers instead of using the built-in amplification. I'm not really worried about EQ:ing the surrounds anyway, just the mains and sub - and with a 2x4 HD that means skipping the LFE channel, which I don't mind that much. Bigger problem is doing another analog to digital conversion to achieve it. Plus it's an integrated amp, not a power amp, and doesn't have HT bypass. All of which raises more quality concerns. So many damned volume control stages! *sigh* Although for stereo listening - that of course being the most quality-critical application - I could at least skip the AVR+2x4 HD with a separate connection from the PC to the integrated amp and use the software EQ I'm using now, though that'd mean I'd lose out on the subwoofer. Or only skip the AVR and keep the sub by connecting 2x4 HD to PC directly.)
I guess it's still something to seriously consider given how long it'll take to be able to buy the new AVR - a year at minimum from how things currently look. I just wish I had an opportunity to test the damn 2x4 HD before committing to buy.