I'm fine with trying to fix the issue, but as an IT guy myself too I tried everything that I thought of and while it's probably a software issue I don't think I have any control over the software.
As said before I tried :
Changing the GPU (I had a 3080 ti before, now 5080), changing OS (linux nixos/kde), reinstalling windows, installing different nvidia drivers version, updating denon firmware....
I also tried with another PC (laptop on AMD integrated graphics) and no issue there.
I also tried disabling HDR, not running 120Hz, disabling hdmi 2.1, using "sound keep alive" softs, looking at plenty of logs (thanks to linux), changing power profiles for the GPU, running dolby atmos instead of multi in etc etc (I don't remember everything)
Only thing I could try but doubt will help is test with a WHOLE other PC but keep the same GPU, I have the PC just need to move it downstairs. But since it's probably totally related to the GPU + its driver I'm not sure it will help.
As you see this comes down to either a problem with NVidia cards vs. the Denon or something on that PC is interfering.
I don't think there is a general problem with NVidia cards and the Denon AVR. Or at least it is very unlikely. Also the AVR does not have an issue by itself, as you see with the AMD Vega or similar iGPU from the laptop. So the problem is confined to that PC.
Dropouts, interfering, reduced speed and general performance problems with add-in cards and peripherals on board can happen. In many cases these are L-state issues, which refers to what the peripheral unit will do when it's not currently interacting on the bus. And if it's interacting isn't necessarily a constant state, more things like interrupt moderation come into play. The PC BIOS knows 3 states, simplified: on, soft-off and off. Represented by 3 L-states allowed to the hardware (PCIe slot in this case). These are there for powersaving and efficiency.
On = no powersaving
Soft-off = reduce the link as max. as possible without going away, the usual standard
Off = go away when not needed, max. saving
Coming back from soft-off is rather fast whereas coming back from off is not so fast. Soft-off can already induce problems for certain peripherals with certain boards vs. BIOS and OS.
When an outdated BIOS and settings are ruled out (hence update and load optimized defaults) the switch for PCIe slot is to be made. In the OS this is represented by the power plan. Win: PCIe no powersaving, mediocre powersaving, max. powersaving.
I can't remember all cases that needed tuning in this area. Older Intel NICs are probably the most common cases. RAID controllers, HBA cards, firewire controllers.. lots of stuff that sometimes easily outlasts a Win version and a mainboard.
Linux won't solve it if the change needed is on BIOS level.
You don't have to do this, but I leave this info here in case someone else runs into this. After all (i)GPU to AVR is not that uncommon. It usually works, but... sometimes needs a little help.