It's my media room which is a bedroom of roughly 17x11x8. So when you have a PC, amps, plasma TV, bodies, etc, it can really add up. If I could relocate the AVR I would do that, too, but there are issues with running Audyssey and accessing it when I need to for HDMI REW measurements. And, I don't feel like making miles of speaker cables.
After all of the feedback here – which, thank you everyone so far – where my thinking is going is that Thunderbolt over optical is the only way to go if you are going to be running all of these peripherals and monitors beyond 1080p since ethernet doesn't have enough bandwidth. Since my current PC doesn't do Thunderbolt, it's looking like I may build a new machine next year, ideally downstairs so it can be hardwired to the router, but we'll see if that will be doable.
Current thinking:
PC -> Thunderbolt over optical -> Thunderbolt dock -> Monitor, DAC, mic, keyboard, mouse, camera, card readers, etc. Laptop can also plug into the dock to use the monitor.