IMO let them point straight forward. Assuming your listening position is at the point of an equilateral triangle you'll be at the 30 degree location, which has a perfect downward slant for high frequency. You don't want it to be perfectly flat. Other room factors (like close side walls) and your age (HF hearing) could change that, but seems like a good place to start.
That is a tough space. Personally, I would bring them inwards away from the walls and pint them straight forward. Then experiment with the seating position (forward and back will definitely change the tonality) to taste. That should give you excellent soundstage. Regarding the sub, really not sure - room modes are unpredictable IRL. Have you learned to use REW? It's mandatory for optimizing the SQ and EQ to your space, especially in setting up a sub.
