Stupid, novice, question but what are the 4 or 8 pieces?
Yes, the thing that worries me, as a novice, is the idea of having to glue the various panels together in an airtight manner that looks good. So, the idea of a single piece unit with a screw on back panel is appealing. I know that this is beyond most home 3D printers but those of us without a printer could take such plans to a local 3D printer shop. (Here a local manufacturer seems to offer 3 prints using metal, fibre and various plastics
https://www.sqpengineering.com.au/services/additive-manufacturing/)
So basically the SPK16 cabinet measures roughly 250x330x450mm (IIRC) and a standard print bed on a consumer-grade printer is around 220x220x250 (LxWxH). As such the cabinet needs to be printed in pieces, it won't fit in the printer in one go.
@Roland68 is correct that these speakers are small enough to print in one go if you get the right printer. Printers that big are far less common but not hard to get if you want one. In that case, it can look pretty decent straight off the printer when things go right. Removing supports from the interior would be kind of a pain, but the removable back would help with that.
A Bambu P1S has a 256x256x256 print bed so you can split the cabinet into 4 pieces, but I'm trying to get it to fit on smaller printers, so it ends up making sense to split it into 8. Front left top, front right top, rear right top, rear left top, etc. etc.
Gluing the pieces together should not be TOO hard, depending on what glue you use. For this I will probably use a 2-part epoxy, (it's thick enough to make sure you get a nice even layer) and I plan to print a little spreader / scraper tool to help get an even coating on the cabinet walls. For tiny gaps, the filling and painting steps should (hopefully) help with airtightness.
The design I'm working on has little dowels that connect each piece to its neighbor, so you just need to put the glue on, slot the dowels in, then clamp it down. If I do that part of the design right, it will not demand much of your DIY skills.
Still, I will tell you right now, no 3D print that's been glued together looks good - just like MDF enclosures, you need to do some finishing work to make them look nice.
In the case of finishing 3D prints, you usually do a quick sand to knock down print or glue flaws that protrude, then slather the piece in some kind of filling compound (bondo, wood filler, etc to fill in any gaps.) From there, you typically use another filling agent that smooths out the layer lines (filling / building primer is popular), sand that, and probably repeat that process a few times to get it really smooth. From there you paint using whatever methods you prefer.
This probably sounds like a pain in the ass, and it is, but it's no worse than finishing wood pieces.
There are buttloads of Youtube videos out there that walk through this process, so if you have the motivation to try, it's doable.