The answer is, of course, it depends. The original idea behind the spikes is that they couple to the floor, preventing the speaker cabinet from vibrating counter to the cone motion. If this happens, one woulh have out of phase signal cancelling the "correct" signal. Probably works for a sealed cabinet running at low frequency with concrete floors and carpet. It get more vague with bass reflex ports and wooden floors. How to tell what is best? Easy, run a test! Easy enough to put a mic in front of the speaker and do a response sweep, or even pink noise with an RTA. Try with and without. Next level is a vibrometer on the speaker cabinet. More difficult to find, but you could figure out the resonance frequency of your speaker/stand combo. The toughest one is something like Newman's LSR6325P on a tall stand. Those are heavy aluminum cabinets (I have several pairs) and they make a great pendulum. Fortunately they are going to rock, er. oscillate at a low frequency. Keep your crossover above that, and it does not matter much. Taller stands and heavier speakers push the resonance to a lower frequency.
There is a company called Isoacoustics that make stands designed to let the speaker vibrate in space. Their intent is to decouple the speaker from a desk or console to eliminate annoying vibrations. They work for that. I am ashamed to admit that I have not tested them to determine the sonic impact. The company rep told me that they actually improve the sound. I doubt that, but without data I can only conjecture. As far as desk stands go, I really like them.
There is a company called Isoacoustics that make stands designed to let the speaker vibrate in space. Their intent is to decouple the speaker from a desk or console to eliminate annoying vibrations. They work for that. I am ashamed to admit that I have not tested them to determine the sonic impact. The company rep told me that they actually improve the sound. I doubt that, but without data I can only conjecture. As far as desk stands go, I really like them.