The estimated in-room response assumes both a certain level of reflectivity, and a relatively far listening distance. Additionally it is usually only accurate-ish above, say, 300-1000hz depending on your room size, this is because it does not account for room modes or other forms of strong destructive/constructive interference (such as reflections from a mixing desk). If your room is not very reflective, or if your listening distance is relatively close (say, 2 meters or closer) it becomes less accurate, and the actual in-room response will look closer to the anechoic frequency response of the loudspeaker.