If your pair of speakers costs more than, say, 200 euros and was designed by a competent engineer, the room is always the weak link. If you have a cancellation at certain frequencies, no automatic calibration software will be able to fix it, because even with more than 10 dB of boost, it will still be there. If the dip is very narrow, you might not notice it while listening, but my experience measuring rooms shows that they are often wide enough to be clearly audible.
Moreover, if you have a one‑second decay in the low end, even the best DSP in the world won’t be able to do anything about the fact that you’ll have no definition in the bass.
Not convinced ? Try to sonorise a drum kit and a bass playing rock in a gymnasium and come back at me…
Now, why is it worse with speakers that go lower? I’ve explained this before, but reducing RT60 below 100 Hz becomes exponentially more complex as you approach 20 Hz. So what’s already difficult at 40 Hz becomes completely unmanageable below that, even with very advanced acoustic designs. So yes, if you buy this speakers to mix music and have a better translation than with less bass capable speakers, it may actually not be trivial at all. Of course, if you just want to enjoy a lot of bass extension, even if it's a little bit muddy and undefined, wich seem to be your case, what i explain doesn't apply to you !