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[No Politics] What you need to know about CoVID-19 by SARS-CoV-2 [No Politics]

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Well, we lost 61,000 to the flu in the 2017/2018 flu season, and didn't bat an eye. No economic shut down, no masks, no panic. At least here in the US, certain people see blood in the water, and are making the most of it.


The "normal" flu is nowhere as contagious as COVID 19 and 61,000 have died so far even with the extraordinary measures put in place; how many would be dead without those measures? More will die and it will come back in the fall, so I don't get your point.
 
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There's many people at home in the UK on full or near to full pay who are having a great time. I heard one describe it as the greatest holiday ever .

Let's see what they think when it starts raining , the weather has been glorious though all this so far.

No good here, it's 41 Euro degrees outside (106 went to the Moon degrees) with intense sun. Good for Vitamin D, lousy for having any outside-the-house activity.
 
I'm lucky that I can work from home (CPA), my wife is still going into work, she works in the office of a small chemical company that makes numerous disinfectant products and has ramped up production of hand sanitizer they're providing to hospitals, nursing homes, etc.

Weather has been colder than historical averages here with some snow well into April, been taking vitamin D!
 
I've mentioned this before and likely a certain public official has discredited it with some bizarre thinking, but Vitamin D levels which are increased by UV exposure (on the skin NOT inside the body). It is also available in gelcap form for those afraid of solar overexposure.

https://hospitalhealthcare.com/covi...t-biomarker-for-symptom-severity-in-covid-19/ Vitamin D has been shown to not only reduce the production of these pro-inflammatory cytokines but to increase the expression of anti-inflammatory cytokines by macrophages. This may be of value given the proinflammatory cytokine milieu observed in those infected with COVID-194 and how this “cytokine storm” leads to acute respiratory distress syndrome.

In light of the possible immune-enhancing effects, a recent retrospective analysis was undertaken of vitamin D status in patients with confirmed COVID-19 infection.3 Using a database from three hospitals in Southern Asian countries, the author categorised 212 cases of COVID-19 infections as mild, ordinary, severe and critical and matched these to 25(OH)D status. Normal was defined as 25(OH)D > 30ng/ml, insufficient, 21–29ng/ml and deficient as <20ng/ml. The analysis revealed that for those with mild infection, mean 25(OH)D levels were 31.2ng/ml, ordinary, 27.4 ng/ml, severe, 21.2ng/ml and critical the lowest at 17.1ng/ml. These differences were found to be statistically significant and hint at the possibly that patients with higher levels of 25(OH)D have less severe symptoms

In summary, while vitamin D is known to have immune-enhancing properties, in the absence of clinical studies, the value of either supplementing or maintaining adequate vitamin D levels to reduce the symptom burden in those with COVID-19 infection remain unclear. Nevertheless, based on the latest analysis,3 it would seem eminently sensible for clinicians to ensure that those infected with COVID-19 have adequate vitamin D levels because this may lessen the effects of the virus and possibly save more lives.

  1. McCartney DM, Byrne DG. Optimisation of Vitamin D status for enhanced immune-protection against Covid-19. Ir Med J 2020;113(4):58.
  2. Alipio M. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus-2019 (COVID-19) (April 8, 2020). https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3571484 (accessed April 2020).
  3. Huang C et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497–506.
  4. Xu Z, Shi L, Wang Y et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Resp Med 2020;8(4):420–22.
https://www.nutraingredients.com/Ar...-and-severity-of-coronavirus-says-researchers

Clear link between vitamin D deficiency and severity of coronavirus, says researchers
By Nikki Hancocks
28-Apr-2020 - Last updated on 29-Apr-2020 at 08:21 GMT

Getty | AntonioGuillem Getty | AntonioGuillem
Related tags: Vitamin d, coronavirus

Vitamin D deficiency may play an important role in the severity of COVID-19 infections so supplementation should be strongly advised at this time, according to researchers after studying the mortality rates across the globe.

Researchers from Trinity College in Dublin, Ireland, studied the high prevalence of Vitamin D deficiency in Northern Hemisphere countries and the possible role of vitamin D in suppressing the severe inflammatory responses seen in very ill COVID-19 patients and in COVID-19 deaths.
The work was undertaken by Dr Eamon Laird, from the School of Medicine at Trinity College Dublin, and Professor Rose Anne Kenny, Principal Investigator and founder of the Irish Longitudinal Study on Ageing (TILDA), in collaboration with Professor Jon Rhodes and Dr Sree Subramanian at the University of Liverpool.
Published as an editorial in the Journal of Alimentary Pharmacology and Therapeutics, the authors point out that it is becoming clear that countries in the Southern Hemisphere such as Australia are seeing relatively low mortality due to COVID-19, which can no longer feasibly be related to the later appearance and spread of the virus.
The study states that all countries that lie below a latitude of 35 degrees North have relatively low mortality from COVID-19, whereas people in countries that lie thirty-five degrees North and above receive insufficient sunlight for adequate vitamin D levels in winter and spring. These include Italy and Spain, which have low population levels of vitamin D.
Mortality rates from COVID-19 are higher at these latitudes, with the exception of Nordic countries, where vitamin D supplementation is widespread and deficiency much less common.
Vitamin D is important in regulation and suppression of the inflammatory cytokine response, which plays a role in the severe consequences of COVID-19 and ‘acute respiratory distress syndrome’ associated with ventilation and mortality in COVID-19.
The report argues that further research is 'urgently needed' to assess whether there may be a correlation between vitamin D status and severity of COVID-19 but says that, in the meantime, governments should be advocating supplementation of the vitamin.
It states: "A substantial proportion of the population in the Northern Hemisphere will currently be vitamin D deficient, and supplements eg. 1000 units per day are very safe. It is time for governments to strengthen recommendations for vitamin D intake and supplementation, particularly when under lock-down Vitamin D deficiency correlates with poor sunlight exposure, age, hypertension, diabetes, obesity and ethnicity—all features associated with increased risk of severe COVID-19."
Public Health England, and the Scottish and Welsh governments have issued recommendations for supplements for all adults from October to March, and supplementation all year round for adults living in care homes or nursing homes, required to wear clothes that cover most of the skin when outdoors, or with dark skin.
The National Health Service has also recommended everyone consider taking 10 micrograms of vitamin D a day during lockdown as they may not be getting enough vitamin D from sunlight if they’re indoors most of the day.
Professor Kenny says: “Similar public health recommendations are called for in Ireland. This advice is of importance given high mortality rates for SARS-CoV-2 infection in our nursing home sector. We are recommending that all nursing home residents take vitamin D.”
Dr Laird adds that whilst vitamin D can be consumed through the diet, supplementation can help ensure sufficient levels in the bloodstream.
He says: “In addition to metabolism in the skin, which is due to sun exposure, Vitamin D is present in foods such as oily fish (salmon, tuna, sardines), cheese, egg yolks and beef liver. However, supplementation is the best means of ensuring sufficient Vitamin D blood levels. As the effects of coronavirus continue, many of us are limited in the time we can spend outdoors, so extra care is required to keep vitamin D levels healthy.”


Source: Alimentary Pharmacology and Therapeutics
Rhodes. J. M. et al
"Editorial: low population mortality from COVID‐19 in countries south of latitude 35 degrees North – supports vitamin D as a factor determining severity"

I would suspect that Vitamin D supplementation would blow Remsedevir out of the water. Probably an exaggeration, but certainly easier than intravenous infusion (and cheaper.) They could be used together. Final comment, the references may not be conclusive but if I was a physician dealing with Covid cases, I would check Vitamin D levels and supplement as needed to bring it up to normal levels.
Interesting regarding vitamin D. I have for years been taking vitamin D3 after reading about how many Americans are actually deficient. It seems that D3 supplementation can also lead to a greater "sense of well being", which I believe I experience, compared to before I started taking it. And it seems like I do not get colds nearly as frequently as before. All anecdotal, of course. Currently taking 5000 iu of D3 per day.
 
The "normal" flu is nowhere as contagious as COVID 19 and 61,000 have died so far even with the extraordinary measures put in place; how many would be dead without those measures? More will die and it will come back in the fall, so I don't get your point.
The point is, even with covid-19 being in addition to the flu, we still can only shut down the economy for so long, which is not much longer. Also, more will suffer and die from economic collapse as well. At some point, we are going to have to accept some level of risk and go back to work. Just look around, most countries are now in the process of reopening. It's a bad situation, but it has to be done. We just have to do the best job possible of reopening in the safest manner.
 
I've been watching epidemiologists on TV and the point that they keep making is that the countries that have been successful in controlling the virus (Korea, Japan, New Zealand, Germany) have placed their emphasis on testing, contact tracing, and isolation of infected individuals along with ensuring those individuals have places to be isolated and daily checks on their well being and continued isolation. These are not cutting edge techniques, rather that they are epidemiology 101. In a previous century large sanitariums were built to treat TB which both isolated and treated an epidemic disease.

On a more personal note, I find it strange that people can be so cavalier about tens of thousands of preventable deaths. This also applies to the flu where there is a vaccine, but only about 1/2 actually get the shot.
 
I will get a payment (though I don't need it).

I wonder if it is "taxable income" or not?

View attachment 61028

I'll wait for the check.

Obama sent me a check, for being a "First Time Homebuyer" - well, I qualified under the rules, though I wasn't.

He was more generous:

View attachment 61031


Taking Govt. handouts. Oh, you Socialist, you. :facepalm: :eek:;)
uhmmmm - Copy.gif
 
The "normal" flu is nowhere as contagious as COVID 19 and 61,000 have died so far even with the extraordinary measures put in place; how many would be dead without those measures? More will die and it will come back in the fall, so I don't get your point.

You beat me to it. My draft was almost an exact copy.
Stop writing nonsense. Your obsessions, conspiracies, and paranoia should be discussed with a professional; not here. You are exhausting.

Not half as unpalatable as similar posts by those who are overly sensitive to views that don't conform to theirs. Make rational responses with counterpoints or you can be seen to be emotively pushing unarticulated beliefs/opinions. Matey is providing lots of information to consider. Your labelling of him is what is offensive. Not his views.

It is intriguing that some members here espouse the 'right' of 'Freedom' but wish to shut down divergent views. Address the views and don't personally attack the member - that just indicates lack of ability to support personal 'beliefs' and lack of tolerance of those of others.
 
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I've been watching epidemiologists on TV and the point that they keep making is that the countries that have been successful in controlling the virus (Korea, Japan, New Zealand, Germany) have placed their emphasis on testing, contact tracing, and isolation of infected individuals along with ensuring those individuals have places to be isolated and daily checks on their well being and continued isolation. These are not cutting edge techniques, rather that they are epidemiology 101. In a previous century large sanitariums were built to treat TB which both isolated and treated an epidemic disease.

On a more personal note, I find it strange that people can be so cavalier about tens of thousands of preventable deaths. This also applies to the flu where there is a vaccine, but only about 1/2 actually get the shot.



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Yep. Science is a game that is played by the rules. One of those rules is that truth is provisional and falsifiable. Another is that we are transparent and look over each other's shoulders. All that was possible here.
The problem in the here and now is that we are in a hurry, and hence the distinction between what a philosopher of science called the context of discovery and the context of justification becomes blurred. Still, that does not justify bleach etc.
 
Not half as unpalatable as similar posts by those who are overly sensitive to views that don't conform to theirs. Make rational responses with counterpoints or you can be seen to emotively pushing unarticulated beliefs/opinions. Matey is providing lots of information to consider. Your labelling of him is what is offensive. Not his views.

It is intriguing that some members here espouse the 'right' of 'Freedom' but wish to shut down divergent views. Address the views and don't personally attack the member - that just indicates lack of ability to support personal 'beliefs' and lack of tolerance of those of others.
You can't make rational responses to what Matey is doing. He is just vomiting any kind of article he can find. I could do the same thing for a different country, but it isn't counterpoint to anything. He is spamming this thread with relatively uncurated content. I just put it on ignore not because of any agreement or disagreement. It is just information overload which isn't helping anything.

In my opinion what he is doing is like walking into a room where there is a conversation and start loudly yelling unconnected sentences with words to sound like he is part of the conversation too. I'm not sure that is freedom of divergent views. I also don't think Matey is doing this with the intent of causing any trouble for anyone or to drown them out. But the result is about the same. So I'm not trying to personally attack Matey, but I'd say I don't like how he is doing what he is doing. I'd like for there to be more Matey in his posts and less quoting of others.
 
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You can't make rational responses to what Maty is doing. He is just vomiting any kind of article he can find. I could do the same thing for a different country, but it isn't counterpoint to anything. He is spamming this thread with relatively uncurated content. I just put it on ignore not because of any agreement or disagreement. It is just information overload which isn't helping anything.

In my opinion what he is doing is like walking into a room where there is a conversation and start loudly yelling unconnected sentences with words to sound like he is part of the conversation too. I'm not sure that is freedom of divergent views. I also don't think Maty is doing this with the intent of causing any trouble for anyone or to drown them out. But the result is about the same. So I'm not trying to personally attack Maty, but I'd say I don't like how he is doing what he is doing. There needs to be more Maty in his posts and less quoting of others.

Well another poster didn't like the 'Matey' in the posts and made accusations against his character. Your reply to that poster indicated support.

I get the impression that many members appreciate Maty's input on this topic. Somewhat more than those who have noted strong discomfort - and they aren't always in agreeance with his posts or interpretation. The good thing is that they can rationally engage without spitting-the-
dummy(pacifier).

I am still waiting for those who are against lockdown, or, for early cessation of constraints to put forward a reasonable case without suppositions that they accuse medical experts of indulging in.
 
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You can't make rational responses to what Maty is doing. He is just vomiting any kind of article he can find. I could do the same thing for a different country, but it isn't counterpoint to anything. He is spamming this thread with relatively uncurated content. I just put it on ignore not because of any agreement or disagreement. It is just information overload which isn't helping anything.

In my opinion what he is doing is like walking into a room where there is a conversation and start loudly yelling unconnected sentences with words to sound like he is part of the conversation too. I'm not sure that is freedom of divergent views. I also don't think Maty is doing this with the intent of causing any trouble for anyone or to drown them out. But the result is about the same. So I'm not trying to personally attack Maty, but I'd say I don't like how he is doing what he is doing. I'd like for there to be more Maty in his posts and less quoting of others.
That's a interesting social observation, i think he was probably responding to the call for information and less 1-1 personal battles but possibly this is a common theme in other parts of the forum too .

There's seemingly no actual communication possible or indeed invited by many of his postings , that's ok but their frequency makes this quite jarring .

These threads , the forum interactions are a mix of conversation and pure information sharing . They do then seem to follow the social rules ( hidden rules ) of interaction. One of which is recognising the others in the conversation and inviting their input in some way .

Else you just have a situation as @Blumlein 88 describes . Still the best way to deal with that is to put the offender on ignore or make room and tolerate it. A bit of constructive criticism is fair but we don't want to be personally attacking people .
 
I found a website that lists various death rates for several countries over the last 60 years:

https://data.worldbank.org/indicator/SP.DYN.CDRT.IN?end=2018&locations=AT-SE-NL-PT&start=1960



One of them is the “crude death rate”, counting everybody that has died over the year.

Typically, 35-25% of these come from accidents, and 20-30% relate to cancer, leaving approximately 60-50% for “illness” as a cause for death, mostly death from lung, heart, digestion or other problems.

I tabulated the maximum and minimum crude death rate and the last available data from 2018. These are the coloured pillars in the diagram.

I then added the average reported death number from Corona for April and recomputed the crude death rate with these numbers. And then I assumed that 30% of the reported Corona death cases might not be attributed to the virus itself. These are the two lines hovering above the pillars.

This graph can be interpreted in many ways, and as this is a non-political forum, I will not add a lot here. But I point out that the spread of the death for the last 60 years for the industrial countries probably reflects the work in mines and other heavy industry in early times. And there was the "Honkong Influenca" in 1968/69. And the low death rate of Mediterranean countries reflects the often cited "Mediterranean diet" and it shows how horribly these countries are hit. And I may just say that it seems statistical saver to live in the US with Corona then in Germany without it.

There is also seasonal & influenca cycling that would increase the Q1 death rates by around 10-20% above average (and then, of course, reducing them in the remaining part of the year).

I have no medical training or other unique insight. I may have made mistakes with this graph, and I am happy to hear about these mistakes.

DeathRate_Corona.gif
 
For these numbers to be meaningful you have to assume a stable population and identical age distributions. However, some countries have witnessed big population increases. This means their deaths are the product of fewer births that happened on avarage some 70-80 years ago.
 
Scott this is not appreciated, this can be a emotive subject so we need to try and approach it with a good degree of tolerance and build in room for the effects of diverging opinions and personalities.

We are all arseholes at some point in time.

Some are even 'ankles'. Aussie slang. Look it up because posting the meaning will upset some souls.
 
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