The question was asked earlier about Mch setup issues, and the main issue there is speaker placement/setup. The good news/bad news story about Mch is that it is more standardized than stereo, so there is much less guessing and tweaking necessary in Mch. Unfortunately, those standards for Mch are sort of buried in a lot of confusing commentaries, often seeing unimportant or nonexistent conflict between setups for Mch music and Mch Home Theater. But, I think it is is fairly simple and straightforward to accommodate both with no conflict.
Most all discrete music recordings adhere to the ITU 5.0/.1 standard. There are minor exceptions by labels intent on going off on some tangent or who idiosyncratically reject 5.0/.1 in favor of 4.0/.1. Meanwhile, HT movies adhere to the DTS and Dolby speaker layouts. Forget about the old, obsolete THX standard from the DVD era. The newest Auro 3D and Dolby Atmos layouts, which I am still far from wanting to embrace, merely add speaker channels in the vertical direction to these same basic 2D schemes.
Here is Nyal's commentary from Acoustic Frontiers:
http://www.acousticfrontiers.com/2013314speaker-layout/
As as you can see, all you need to do is set up the speakers in the ITU angular array at zero, +/- 30 and +- 110 degrees for 5.0/.1. For 7.0/.1, add two back speakers at +/- 150 degrees, and you are nearly done. All these angles are relative to the sweet spot aka the MLP. All speakers are pointed directly and frontally at the sweet spot, even if they are bi/dipoles. (On that note, the special "surround" speakers you often see, with angular, not front/rear, bi/dipole sets of drivers are really for THX. Avoid them.) I am extremely happy with this angular setup for both music and video.
Setup assumes either equal distances of all speakers from the MLP or it assumes DSP correction (interchannel delay) for distance. They are functionally equivalent, though purists insist on equal distances for reasons unknown (unless they are using an analog Mch preamp, which has no delay compensation). It also assumes channel levels are trimmed to equal loudness at the MLP on mono test tones from each channel. Auto calibration for this by a supplied mike is built into even the cheapest AVRs. Ironically, very expensive Mch prepros usually require manual distance and level calibration by tape measure and sound level meter or mike.
I much prefer the auto calibration procedure acoustically sensing distance and level by mike and built in test tones, especially for subwoofers. Many subwoofers have input networks that cause additional delay in the signal. Tape measure distance to the sub would therefore understate true acoustic distance including the sub's internal delay. Again, it is ironic that cheap AVRs handle this properly, but expensive prepros usually do not. Sub makers generally do not publish how much delay their subs introduce. I guess you have to contact them for that information if needed or try to measure it yourself via a calibrated mike and analytical software.
But, subwoofer setup and optimization is a whole different topic, including crossover setup. Just crossing everything over at 80Hz often does a great job, provided all main/surround channels have measured in-room response extending down to that frequency or below. Specs alone cannot be completely relied on, as room and placement issues might cause major differences from the specs. Response measurements may be called for, if not provided by built in DSP EQ calibration. Sub tweaking, as we know is a potentially complex subject - single vs. multi subs, etc. I will not go into it here. My own single sub setup in an 18x13 room was straightforward and the results quite satisfactory (with Dirac), though I am sure I could be tweaking it to death if I were obsessive. I would rather be listening to or watching music.
On speaker selection, best theoretically is identical main/surround speakers. Second best, theoretically, is similarly voiced speakers all around from the same manufacturer. Three identical speakers just across the front might improve on that. The other approach is mix and match, or mishmash, but that might even work decently, especially if you use full range DSP EQ, which will voice all channels more equally. Horizontal center channels are looked down on for music, but that is a compromise I use with success.
I think my system, with 7 Martin Logan stat hybrids, 3 different sizes plus the horizontal center, holds its own on music against the arrays of identical speakers I have heard. Someday, my ultimate dream system will embody all the theoretical ideals. As everywhere, the perfect is the enemy of the good, and I think my system sounds pretty good especially on music, but also with video material.