Price will be the biggest issue, $4K for the DPR-16 vs $3500 for the Tide-16. The Tide 16 includes the whole Dirac Suite whereas for the DPR-16, it will likely have to be purchased on a per module basis (chi-ching chi-ching). The webpage for the DPR-16 indicates: "Hyperion also supports modular Dirac-licensed software extensions—such as Limited or Full Bandwidth Room Correction, Bass Control, and Active Room Treatment.".
Dante or AES67 is expensive to implement. If you buy speakers with Dante/AES67 connectivity, typically they're more expensive than traditional speakers with crossover networks even when you consider the component reduction (crossover/DAC/amp) from a traditional audio chain. For Dante/AES67 speakers those components just pile up inside the speaker in multiples, i.e. a DSP board plus a DAC/amplifier combo for each driver, this quickly adds up. Furthermore, you have no control over the selection and specs of the DAC and amplifier technology used in a Dante/AES67 equipped speaker. Trying to add DIY Dante/AES67 to your own speakers by guttting out the crossover and replacing it with a DSP based crossover board with multiple outputs suitable for those affordable high-performance DACs that Amir tests and adding a DAC/amp for each speaker driver also quickly adds up. I've searched and it's hard to find affordable DSP crossover boards with the desired multiple digital outputs, they're often only two-way designs and they usually have an I2S interface, so add an extra I2S to SPDI/F module to feed the DAC.
Another miss for the DPR-16 is the lack of USB audio playback for those who want it. Audio playback other than through one SPDI/F jack or one Toslink jack and HDMI is all network based with Dante/AES67. And let's not forget a complete lack of any analog input whatsoever; sorry vinyl lovers.
One thing that I find surprising and amusing for the Hyperion APR-16 ($8K), its big brother that has 16 analog balanced outputs with ESS Sabre ES9039QTM DACs, is the owner manual. A real lightweight at only 36 pages. Are you kidding me?