Hey OP, I think you may be overthinking the difference between what you think you want and how the miniDSP Flex with Dirac Live actually performs. When building my office system, I also wanted something to correct the subs independently, but nothing outside of AVRs seemed to do this. Luckily for me, it turns out that in practice Dirac Live's full range correction works tremendously well. It absolutely does DSP correction on the subs — it's just combined with the mains. This also gives you stereo bass, which sounds better to me than a mono bass config where the subs act together, but I'm not getting into that here as there are long and deep threads on the topic.
I've had a 2.4 setup using the Flex and Dirac Live for 3 years now, plus a t.racks 4x4 mini as a downstream DSP to handle delay/routing for the extra 2 subs. My setup is Dirac Live only and contains no REW filters or MSO or any of that, and it's excellent. The config is just delays, crossovers, routing, and then Dirac Live. I tried messing with REW, MSO, and other stuff, and hilariously Dirac Live would pretty much correct back to the same thing each time, and nothing sounded any better and only added complication and time. For my 2.4 setup, each main is paired with a front and rear sub. I use a standard 80 Hz crossover, with delay added to the mains and front subs since they are closer to me. Dirac Live sees each 3-piece combo as a single Right and Left speaker, and then corrects accordingly. A 2.2 setup is even easier as it doesn't require a second DSP for the additional routing and delays.
1. Set crossovers, levels, and any necessary delay between subs and mains. The delays will be necessary unless each sub is directly next to each main. You can figure that out with REW or a measuring tape. I did both, and REW just confirmed my measuring tape. Levels between subs/mains aren't terribly important, as I found Dirac will smooth the response either way.
2. Once each channel is configured, Run Dirac Live
3. Confirm your result with REW if you care, and then you can tweak the Dirac Live curve to your liking. Not necessary though.
4. Enjoy
TLDR: I really thought I needed something that corrected each sub independently, but it turns out that 2 channel correction actually works incredibly well for stereo music.