I use the SHD "studio" version which allows four channels to be processed through two AES connectors. I use it *only* as a crossover in the digital domain - no other filtration.
If you are running this device as a DIRAC processor I fear four channels, full spectrum may be beyond its capacity. I use mine with DIRAC disabled.
In my opinion it's an excellent Digital preamp with a straight forward suite for simple manipulations - but the sound of DIRAC corrected output wasn't an improvement for me.
Above 300 hZ there are audible changes that don't sound better to me. With my subs crossed over around 100 hZ no processing seems necessary.
The MiniDSP manual illustrates using it as a crossover/filter either with two way designs or adding subwoofers. (Section 9.3)
"Finally, we’ve added a second pair of outputs and a suite of our powerful but user-friendly DSP audio tuning software - ten-band parametric EQ per channel, crossovers up to 48 dB/octave, compressor/limiter, and a 2x4 matrix mixer — for powerful audio system tuning in applications ranging from integrating a single subwoofer to a two-way active speaker."
While you theoretically
could run a sweep for each speaker and use the device to process output on all channels; I would anticipate instability, artefacts and hash on playback.
https://www.minidsp.com/images/documents/SHD Series User Manual.pdf