Merc have never had a manual 'box that could take the torque of the bigger engines. The market, at the time they would have engineered such a thing, was mainly for big luxury cars at the big engine end. They didn't buy AMG until later.Manuals are more fun. Automatics are often faster, but that doesn't matter on the road. Mercedes rarely did manuals in the US. Very rarely.
My 500E has a 4 speed auto and the speed limit of 150mph is achieved by the rev limiter, so top gear is pretty short even though 1st is fairly long for a sporty car. This is good for performance but not fuel consumption. If I press on I get 200 miles from a 20 (Imperial) gallon fuel tank
The AMG (still before Merc owned them) mods to the car was mainly fitting a long final drive so the top speed from the available power was achieved and some bigger wheels and spring/damper changes.
The F1 driver I was working with at the time had an AMG version and asked to drive mine to feel the difference. It was a wild ride, as usual, but he said it actually felt quicker than his at road speeds because of the gearing.
Anyway I still have and love it, cost of spares has been moot since I haven't needed many.
Mostly I drive a plug-in hybrid Prius or an open sports car nowadays though with petrol at £5-6 per (Imperial) gallon.