There are 2 reasons for using multiple woofers/subwoofers -
1. To get strong-loud-deep bass. (You can't get the "realistic sound" of a kick drum or bass guitar from a 6-inch woofer...)
In "small rooms" (any room in a house) you get standing wave
Room Modes where certain direct and reflected waves combine in-phase at certain frequencies and certain places in the room to make a bump-up in frequency response, and at other frequencies and other places in the room they combine out-of-phase creating cancelation and a dip in frequency response.
The bumps and dips can be evened-out with multiple subs at different locations. (Your column won't help much with that.) ...Not always practical in a home environment.

Another solution is bass traps which to absorb the waves that would otherwise be reflected, again smoothing-out the dips and bumps. Bass traps are usually big and bulky and you have to cover a significant amount of wall area. "Regular" acoustic treatment doesn't do much for the bass and it's often unnecessary.
You can fix the bumps with EQ but the dips/cancelation is more difficult. It takes nearly "infinite power" which you may have (considering the home environment) and nearly "infinitely large woofers" which you WILL have!

EQ only "works" at one place the room so if you have a home theater situation with several viewers/listeners, some peopel will get "imperfect" bass.
Fortunately, the hard-to-fix dips are less annoying than the "boomy sounding" bumps.
BTW - I forgot to say... I LOVE BIG SPEAKERS! My "speaker stack' in my living room is almost ceiling height (almost 8-feet tall) with the subs on the bottom and tweeters on the top angled-down. Some people would complain about the "imaging" with the tweeters higher than ear-height and higher than the midranges, but I listen to rock, and I'm a bit crazy! ...I "only" have a pair of 15-inch subs in large ported cabinets, and no bass traps or other treatment. ...It's just a normal carpeted living room. I'm satisfied and I can "rattle the walls" or annoy the nearby neighbors... I also built a pair of 8-foot LED "VU meters".
You should understand what frequency response is and what a frequency response curve looks like. If you experiment with the speaker design software and make a good design you can make electronic tweaks later. You're pretty-much stuck with the driver & box size, although you can add or block a port, or change port dimensions. With huge well-designed subwoofers you can't go wrong from there!
BTW - Ported boxes are more finicky than sealed boxes... A random ported box is likely to be BAD, whereas a random sealed box is usually OK. But either way, the software can help you to make a good speaker.
If you have an AVR (audio video receiver) the bass crossover ("bass management") is taken care of. That's the most common and easiest way to add a subwoofer.* Normally it's an active sub but you can use your own power amp. Many AVRs also have "room correction" (Software that measures and EQs the frequency response).
Some active (powered) subwoofers have built-in line-level high-pass filters to cut the bass from the main speakers (and low-pass to the internal amplifier). You can also build an active sub and there are "plate amplifiers" with crossovers and other EQ or DSP built-in.
Or there are active line-level
crossovers.
All 2-way or 3-way speakers have a crossover inside.
Once you've built your speakers and everything is working you can
consider downloading
REW (free) getting a measurement microphone (about $100 USD). to measure your speakers and room. ...Especially before acoustic treatment, etc.
"Diagnosis before treatment".
* Bass management is an optional setting. You can set your AVR for "large speakers" and the regular speakers will get the regular bass from the stereo and surround channels. In this case, the sub is only used for the "point one" LFE channel, so the sub isn't used with regular stereo at all. Also, without an AVR (or other surround decoder) the LFE channel is lost and you only get the regular bass (It's not used in the stereo down-mix).