In my career I have worked on the development of several devices and treatments for the heart and cardiovascular diseases that required double blind studies where the control was non treatment or drugs, so there was very little chance for a placebo effect for patients that got device interventions. It was clear within hours to days improvement was or was not there. But in drug studies were the patient know they received the real therapy placebo is an issue. But if the patient is told in advance that they have 50% chance of getting the sugar pill the placebo effect goes way down. Placebo comes with an expectation of success. "Wait until to you hear how much this cable improves the sound"