It depends on the speaker. A speaker with a shelved bass response (e.g., the KEF R3), sans EQ, is going to sound anemic pulled out into the room. On the other hand, a speaker designed for a flat bass response anechoically is going to sound boomy if placed against the wall (some people might like that, though).
Another issue is the distance of the speakers from the listener. In my family room I have experimented with my speakers against the wall, about 4.2m from my listening position, and pulled closer to me, about 3m, with room correction applied for the respective positions. I hear more precise imaging and a wider sound stage when the speakers are pulled into the room closer to my listening position.