It works!
In my main desktop system, connected to my older Modi 3 Schiit DAC, Synapse had no noticeable sound improvement. But I just tried it with my old Schiit Fulla v1, which was basically unusable because of all of the electrical noise it would pick up from any computer I tried it with (on top of the volume pot sometimes being a bit scratchy). Well, I just used it with two different laptops, the Synapse eliminated the USB noise completely and the old Fulla sounds pretty good.
So for DACs that are prone to pass-through noise, the Synapse can make that problem go away for $54 shipped (in the plastic case model).
I had to order a USB-C to USB-Micro cable to get connected to the Modi, as this older DAC version unfortunately uses the Micro jack and JDS does not have a USB-A to Micro adapter in their package. No biggie.