You'll first need to verify that the -ve speaker terminals of the L & R channels are common. Use a multimeter to measure the resistance between the two -ve terminals, if they are shorted together, you can use the amp as bridged monoblocks. From the picture below, it looks likely.
Note that the minimum speaker (load) impedance will be increased from 4 Ω to 8 Ω.
Second step obtain a device to generate a reversed polarity copy of the source signal, and supply it as the input for the second channel.
If you use the left channel for the normal signal, and the right channel for the reversed polarity signal, then connect the left channel +ve speaker output to the +ve speaker input terminal, and the right channel +ve speaker output to the -ve speaker input terminal. Leave the -ve speaker outputs unconnected or short them together using a short piece of jumper wire.
The trickiest part is to generate the reversed polarity signal. Easiest is to use your miniDSP Flex to generate them, but you will be using up two additional output channels. May be OK if you have a Flex 8. Otherwise you'll have to find or DIY something (e.g. something start from an
opamp evaluation board).