I have been playing around with some mains and subs with similar goals to the OP and if you just look at the "maximum output" specs you would not think it would be too hard but as mentioned LF and HF output are much lower than the quoted "maximum output" specs. Neuman has a graph which shows this for their speakers, in this case the KH 310's, which make this issue very clear (most speakers behave in a similar way).
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The other issue that comes up is subwoofer response. The 7382A sub is 6 dB down at 100 Hz and many "Hi-Fi subs" are similar. This is in contrast to "Large PA subs with Pro drivers" which have huge output between 100 Hz and 200 Hz but roll off below 40 Hz (because they have such high SPL this can be compensated with a high shelf and room reinforcement). When "testing" in addition to measurements I use Neumans "kick drum train" test which has a very wide spectrum with the highest output at ~100Hz. At high volume crossed at 80 Hz this brings the KH310's to their knees with the red light flashing. Moving the crossover to 120 Hz (I have very large subs with 18" pro drivers) solves the clipping problem but brings up 2 more which is some Hi-Fi sub are not really suitable to cross at 120 Hz and localization can become an issue. My solution was to co-locate subs and mains with linear phase crossovers and live with a little uneven measured response in exchange for stereo bass, accurate timing and high SPL. With a multi channel system these issues are just multiplied.
To answer the OP's question the Meyer system can meet your SPL requirements much easier than the Genelecs but with the number of speakers you are looking at both can probably be made to work but integration may be harder than you would think even with all the fancy "automatic DSP". Some compromises and choices will probably have to be made but these are high level issues and both systems will be a lot of fun!