I’d run them in stereo. I don’t think standing directly under the speaker would be any different between either of them, so would get the bigger ones if they fit. KEF also has in-ceiling subwoofers to complement them (along with amp with appropriate DSP).
Engineered to deliver incredibly accurate and powerful bass, Ci250RRb-THX is the perfect addition to any music or home theatre system and an excellent partner to other KEF loudspeakers. Featuring an extra-long-throw 250mm (10 in.) bass driver with a massive 150oz magnet, Ci250RRb-THX delivers...
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Whatever you do, please post pictures of the install.