I wonder if it was the built-in DC/DC PSU, and using a standalone 5V PSU for the device would have fixed the problem. I would be really surprised if those new chips were having issues with USB2 highspeed when that is their only purpose.
It's not about speed issues.
In the case at hand, disconnecting the positive supply with an external power supply would likely have had the same result.
But again, there are several potential problems.
The two basic chip solutions from TI and ADI naturally have limited functionality and were developed as inexpensive standard applications. Of course, the implementation of the ICs and the DC/DC filtering are also crucial.
Therefore, there will likely be differences between the various implementations.
The Intona is a very sophisticated bidirectional isolator/reclocker/repacketizer at the physical level, which has been used for over 11 years in all areas of industry, medical technology, science/research, aviation, etc., and must function without any limitations. It also has a protection function, as devices with 4, 5, or 6 digits are often connected.
The firmware is also customizable if needed, and Intona has a head start of about 15 years in this area.
You would have to delve deeper into the subject, take your own measurements, and analyze the various different cases.
But what's the point if you can avoid these cases altogether?
Used Mac Minis and HP business desktops and notebooks in good condition can be found for €150-250. I've never had any USB problems with audio using these, and the use of an Intona USB isolator (or any other) is completely useless.