Oh yeah... There's a difference.
Between analog through the Dac8 via USB and digital via AES/EBU, I find the digital setup has the edge on transparency (to be expected). And I can hear it clearly. Not night and day, but the recordings sound subjectively a step "more real".
I finally hooked up everything together. It's a little complex... And used GLM to calibrate the monitors for analog and digital inputs. I stored the analog settings in the monitors so they are present even if GLM is off.
GLM is essential to have them sounding at their best. Bass is soooo tight and articulate now that I have a custom calibration for each monitor. It's impressive... And it goes deep. Much deeper than my previous amp + passive speakers or the 8030C in midfield duty. I don't feel a need for a sub at all. The house shakes with some heavy electronic music like Trentemoller's "Evil Dub", it's deep and articulate.
Imaging is also excellent and very precise comparable with the 8030C. But the thing that impresses me the most is how cohesive and detailed the sound presentation is. Good recordings feel very real. Like the mics are connected to my brain directly. It was a worthy investment for sure.
I think the 8030C also have similar qualities, but the 8351B does it better and bigger. Not really a fair comparison, but my point is that they are both excellent. The 8030C works really well in my home office attic space.
And finally, the Design stands are excellent in hiding all the cables needed for the analog, digital, GLM, and power connections. I still need to work on cable management outside of the stands..