Fuses besides being sort of electro-mechanical, basically age every time you turn something on, they get older, like the filament of a tube. This wear and tear affects them physically, for example, the tin plating on an old fuse wire can migrate into the wire a bit, so the actual fuse element is weaker.
And, if the fuse is running near its current interrupt point, it can have a measurable affect on distortion with the right input signal. Also, you may have noticed that fuses sometimes blow at turn on after you have been running something for a long time,
ie you turn it off then turn back on and the fuse blows, this is from wear and aging of the fuse, or from the fact that a fuse is set up to work correctly when cold vs when near its interrupt rating at turn on, ie if you have been pounding out the tunes all day at a high stress level for the fuse, then switch the amp off then back on, well, the fuse is not cold, its hot, and the I squared T thermal function will already be nearly ready to blow because of the existing heat. So, these things are not just a simple thing. A blown fuse, first time blow, is not always a circuit problem, but could be just a tired old fellow who has seen better days, so sad, reminds me of me ahahahahha