There is no universal "should", as the in-room response is a combined result of the speaker design, speaker placement, listening position, and your room.
Especially the bass will be heavily influenced by room and speaker placement (and listening position). Headphones are different since there's no room to mess up the result.
So if you have competent speakers, you should not EQ the response to a target, as there is a natural, correct response that automatically happens when the speakers interact with the room. Most "normal" speakers will show a slope with less energy in the top end compared to the bass. The bass level, say at 50hz (not including peaks in the response caused by the room) typically ends up somewhere around 3-10dB above the midrange/highs (2-5khz). As roughly indicated by the Harman graph you posted.