I also feel compelled to mention that it was
fashionable for a while to run tubes like a 12AX7 (or even some of the neither fish-nor-foul Chinese small signal tubes that have no exact "western" counterparts) at really low plate voltages, taking advantage of the "space charge effect" to make very wimpy but (barely) functional amplifiers.
It's a bit off-topic

but in the last days of vacuum tube car radios there were a number of specialized "space charge" tubes developed for automotive use. While "good" (inexpensive) audio transistors were available by the very early 1960s, transistors for high frequency (RF and IF amplifiers and oscillators) applications were uncommon and/or expensive. Hybrid tube/transistor car (AM, mostly) radios became moderately and briefly common in those economically-challenging times. There was intense interest in getting away from noisy, heavy, expensive and somewhat unreliable "vibrator" power supplies, so a family of vacuum tubes
designed to run with a plate voltage of ca. 13 volts (car DC system voltage) were developed. Lots of them were made, relatively few were used, and they were (and to some extent are) available NOS at very modest prices. These appeal to the DIY/lunatic fringe vacuum tube hobbyists.

See, e.g.,
Tube projects don't always require lethal voltages! Some tubes were designed to run at 12V. Others were not but work well anyway at B+ down to four volts.
www.junkbox.com
Much more recently, engineer/audio designer Pete Millett, e.g., designed an entry-level hybrid headphone amplifier/linestage using a space charge triode and a solid state buffer as a way for the true neophyte to play with a vacuum tube audio amplifier without having to worry about those pesky lethal plate voltages!

Here's the original morph, in a "reprint"

of the original
audioXpress article at Pete's website:
He latter updated the design, but the only one I have experience with is the original.
Apropos of (almost) nothing: here's one of the several I've built, with a blue LED pilot light
and illuminated with a blue LED flashlight.