guitar input routed to the 2x analogue outputs, audio file playback routed to the 2x AES outputs. Routing achieved via DAW software.
Sounds like the best option - no additional audio interface hardware required. Reggiejackson if you want to test that this will work before you go out and buy a Topping DAC and AES-S/PDIF converter, I suggest you could buy this cheap S/PDIF DAC -Yes, it should work like that, but it needs the AES DAC for that. With pro audio devices you always have to rely on the software, including routing
https://www.ebay.com/itm/196267830401
Make up a female XLR-to-RCA cable, or if you don't know how to solder, instead just buy this adapter -
https://www.ebay.com/itm/313295536442
then connect the AES output of your SERAPH AD2 to this DAC, and play around with your Marian Mixer app and DAW software to see if everything works.
It might be worth telling us the details of your software setup.