Should? That depends on the pattern one needs. Looking at the radiation patterns for these Peavey cabinets suggests enough symmetry that orientation probably doesn't make much difference.
At my church, I chose JBL CBA-50 speakers that comprise five 2" drivers in a phased line array. These specifically provide a wide horizontal pattern but a pancake vertical pattern. The pancake is designed to float over the microphones and first several rows of the church (that don't need sound reinforcement) to provide reinforcement to the back of the church while minimizing ceiling reflections. Those need to be vertical in most applications.
Rick "who also used a Crown amplifier" Denney