This is a very interesting challenge. Imo the combination of characteristics you describe generally point towards a cinema-style horn system, but with optimization for sound quality rather than most efficient audience coverage. Very big cinema-style horns tend to be optimized for attributes other than highest possible sound quality.
Without knowing the physical layout you have I don't know what radiation pattern widths would be feasible, so that would be one of the things I'd want to look at.
In a 90-degree horizontal pattern width, the PBN M2!5S comes to mind as a theoretically higher-output alternative to the JBL M2:
https://pbnaudio.com/m25-loudspeaker/
My understanding is that member
@Bjorn has something interesting which is pretty far along in the development process, and his horns are works of art:
https://www.audiosciencereview.com/...audio-midrange-horn-polar-measurements.42732/
I've done some work with large-format off-the-shelf studio-style horns and some with large-format custom horns, but again I'd want to look at the coverage patterns required.
Imo the solution north of the subwoofer region will help to define what the subwoofers need to do.
One outright recommendation I will make, if you don't already have an acoustician: Jeff Hedback of Hedback Designed Acoustics. He is a multiple-award-winning studio designer who also does high-end home audio and home theater rooms, and he is still affordable. The most far-reaching decisions are made at the beginning of a project like this, which is also when you know the least, so imo this is the stage when outside expertise is the most beneficial. Jeff works remotely so geography is not an issue: