We lived in a caravan, travelling, for 5.5 years. All my music FLACs and MP3s (and films, docs, etc) was stored on a NAS-RAID with DLNA. They sounded fine and still do, and since going back to living in a house, I have re-ripped loads of CDs from my collection (which were in storage, in a shipping container) just to check they were still in playable condition. All were fine. Using totally different hardware for the rips, I cross-checked against the old rips on the NAS, and according to the excellent FB2K, the rips were all bit-identical. The first time I ripped, I would have gone for the fastest compression to save time, but sampling CDs for the 2nd rip, I used higher compression (longer time to process), but the data bits in the files were identical.
I think that a NAS-RAID unit be will be slightly heavier if you use lower compression, compared with high compression, all other things being the same. It's to do with entropy and energy, so I'll be getting out my Planck-length microscope to check if the treble still sounds good in my FLACs....