Yes, speakers can be too big for a room.
It takes a certain listening distance based on the size of the speaker baffle, or more precisely the distance between contributing drivers (talking conventional multi-ways),
before the phase of the various drivers settles together to form the
acoustic far-field. (Not to be confused with studio speak far-field.)
Any measurements or listening positions within the acoustic near-field, where phase summations are still chaotic, will vary much more position by position, than for the same degree of position change in the acoustic far-field. Kinda like, all bets are off what you will get, in the acoustic near-field.
I'm pretty sure Genelec and other manufactures discuss this phenom on their sites.
edit: here's snip from Genelec's Monitor Setup Guide. The highlighted yellow is about phase settling distance.
A decent room of thumb is that listening distance should always be greater than 3-4X longest speaker dimension (again talking conventional multi-ways.)
Generally easy enough to do,...... until room is small and speakers are large.....
View attachment 436735