Are we talking about the same situation as Rob Watts described with the ASR Mojo 2 tests?
“The issue here is the APx 555, in that the analogue oscillator is permanently on internally even when it's turned off - at least that's my supposition, as the APx 555 permanently creates analogue ground noise at 1kHz intervals and with careful measurements this signal will become visible. The issue is the APx 555 creates a 1kHz signal current, which flows out of the USB port, into the device under test (DUT) then back into the APx 555. Due to finite ground impedances, this creates an error voltage, which is then picked up by the APx 555 input ADC. But this error is nothing to do with Mojo 2, but a problem with the APx 555.”