I own the two-way Genelec 8330A’s, the three-way coaxial 8351B’s, and have owned the three-way Neumann KH310’s. Between two-way Genelec’s and thee-way Neumanns, I would choose the latter. The KH310 come pretty close to the overall sound quality and power of the much more expensive 8351B. The coaxial Genelec’s are more flawless in some ways, but their price is almost twice the KH310’s.
I cannot speak directly from experience as I have not heard the 8350A, but if you’re willing to use REW and a miniDSP mic to calibrate Neumann KH310’s properly, I suspect it would be pretty hard for the 8350A’s to compete in terms of THD, IMD, etc. So I would choose the Neumann KH310 if I was in your position.
However, there is one exception: if you plan to listen very “near field”, the horizontal symmetry of the Genelec’s more traditional layout may be an advantage. The KH310’s are best for “mid field” listening, about ~1 meter or more distance to listening position, as it’ll take that much distance for the drivers to all integrate well horizontally.
Other reasons to choose the Genelec 8350 (even if the KH310 may have sonic advantages): Genelec has automatic sleep features, while the KH310 will always keep the class AB amps powered up until you physically power them off or cut the power. This means that the heat sink on the back will be warm to the touch, and the amps will wear out faster than the Genelec over time if you don’t manually (or otherwise) cycle power when not using them. Lastly, if it is too much trouble to calibrate the Neumann’s manually via your own DSP solution, the Genelec is better with the GLM kit since it makes calibration so easy. However, unless you plan to use Genelec smart subwoofers also (which are not that great performance for the price, at least in the US market), you’ll probably be forced to use your own DSP anyway so it probably doesn’t matter as much if you plan to use a third party subwoofer.