You should test this, blind and controlled. Or realize the belief that amps have sound is has been tested exhaustively. Or even more specious, that the sound of amps has yet to be characterized.Definitely not a placebo. In fact, said listening fatigue is what pushed me to fully treat my room, I assumed it must be from reflections, and I was wrong. I spent ages in REW and even made posts here about it, nothing worked until I switched to AB. In fact, even my older crappy AB receiver that I had before I got the D amps did not cause this issue, despite sounding much worse.
Since switching to the B200s with everything else exactly the same, no issue. I bought them from amazon specifically so that I could return them as I assumed slim chance it will fix the problem, and it did.
My hypothesis is that it's similar to older LED lighting where the color temperature and lumens would measure just fine, but people would get inexplicable headaches due to the speed of the flashes of the diodes. This has been resolved with modern LEDs of course, but those people were not imagining that despite it not being immediately obvious what was going on.
I can listen to a good quality class D and in the first few minutes think it's awesome, hence why I bought them as when I listened to others I thought they were great. But I didn't sit and listen for a long time, so I had no idea that this was even a thing.
Likely find it is your perception of certain amp types, not the sound. Less likely is you find you have a hearing malady irrespective of the amp type. Zero likelihood that your amp induces fatigue.
This perception is pushing you to do things and spend money on unuseful audio activities. Kind of the opposite of the purpose of the formum.
Switching amps doesn't solve listening fatigue, unless you have a really horrible amp, which you don't seem to own. And randomly buying and returning is a waste of your and the vendor's time and money.