For me, it's not about the highest frequencies, but rather that high res music seems to have a smoother, more natural sound to it. Certainly, at my age, my ears would not be able to pick up any advantage in the highest frequencies, anyway. I also notice the same increased smoothness and more "organic" sound of the music in the lossless Blu-ray formats, compared to the old Dolby Digital 5.1 discs. I guess this all could be due to expectation or confirmation bias, but I don't think so, as I'm pretty skeptical of claims of superior audio performance due to new technologies.