ART will disregard directional bass setting on D&M bass management, as well as any other settings like crossovers. So that's not a way to go directional with ART.
The most directional 2.2 setup, as you say, would be to create profile/calibration with 4 groups. L, R, L sub and R sub (subs being right by L/R speakers). Then support L with L sub and R with right sub. This is pretty much guaranteed to provide you with maximum "spaciousness". However, as
@thcdru2k noted, this is a trade off with the overall performance of traditional cross-support ART system - which I also noted in my previous post. Unless very lucky with the room or the room is heavily treated, including low bass traps, FQ response and decay (to name just two - most important IMO) will not be that great.
So if you don't like the overall performance of the most directional setup, next step is to keep adding support from other speakers and subs until you get to the point where it is balanced. As
@JRowland noted, stretching L and R low support to the max (but having in mind the SPL and distortion as well) would be beneficial to retain as much spacial clues as possible.