Should be true with the exception of the wording whole system, ART only works between 20Hz and 150Hz so within that frequency range should be true is my answer. I would think as with anything it is situationally dependent.
The more drivers that work in the 20Hz-150Hz range the more options you are giving the AI within Dirac ART for correction filter options. If there are only 2 speakers the options are limited, if there are 21 obviously the AI has a lot more work to do finding the best combination but it has way more options. As a user you determine what is "available" to the AI. Not only what (group or speaker in my case) but where (what frequency range is available) and how much (support level) you are offering. AI figures out "the best" solution and presents the filters. As an advanced user then you can review each group and the filters applied to make sure they are ok for you, compare them to other "snapshots" (saved filter calculations), and make any adjustments you deem fit. You can calculate over and over again until you are content and then upload your final result. Then crank it and see if anything is going to break
In a nutshell my opinion is that every room and system are different so "it depends". I know if I was building from scratch now I'd still do it the same way (best quality speakers I could $tomach in each position) and at least one sub on the left side of the room and one on the right (that's my preference, one good sub would probably do). If I already had say "poor performing" surrounds I would try adding subs because it is easier for placement and cheaper most likely. I could imagine ART making a good system out of bookshelves that can do above reference volume levels at 80Hz with say 4 subs that perform from 20Hz to 150Hz. I could also imagine 5 quality speakers that all hit reference levels at 40Hz and one sub the performs from 20Hz to 100Hz working similarly as well depending on the room.