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A few questions on potential RME ADI-2 setup

Yes it can, along with sending all of the other inputs,, and being able to play back separate channels to all of the outputs. This means you also have an option of sending properly mixed analog to subwoofers and digital to speakers (e.g., Genelecs, Neuman, KEF LS50 IIW, etc.)

Also, VB Audio Matrix will also be able to take as input anything being played on the PC (e.g. from your browsers, audio apps, etc.) as well as capturing the input (i.e., routing & mixing) for anything you send to the PC from another devices (e.g., to USB or S/PDIF ports on the PC).

Similar for Mac, using audio drivers available for MacOS.

And, for any event where your PC is down (e.g., bad board, crashed disk, software having issues), you can always fall back and simply have the RME ADI-2 route audio directly from any of the input to the audio outputs so that it completely bypasses the USB send/receive until you get the PC fixed or software issue resolved.

For the USB IN (RME Inputs to PC):
  • Channels 1/2 = Analog input (from Neutrik, so unbalanced or balanced)
  • Channels 3/4 = AES (or S/PDIF)
  • Channels 5/6 = S/PDIF (or ADAT)
For the USB OUT (PC to RME Outputs):
  • Channels 1/2 = Analog 1/2
  • Channels 3/4 = Analog 3/4
  • Channels 3/4 = AES (or S/PDIF)
  • Channels 5/6 = S/PDIF (or ADAT)
Copied from Page 43 of the ADI-2/4 Pro SE (v1.3) manual. Configuration information is essentially identical on the ADI-2 Pro FS. And keep in mind that for simplicity, this diagram does not reflect the option to change the mapping of the second set of analog outputs on the back from Analog 1/2 to Analog 3/4. Highly recommend downloading and reading through their manual for the ADI-2 or 2/4 Pros...
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Thank you!
And apologies to the OP for dragging the thread off topic
 
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