I haven't built any 3D printed speakers but I have thought about it a lot.
IMO Printing a speaker cabinet that can compete with 15-19mm of MDF is not very practical. You would have to do solid or nearly solid, very thick walls, which works against the strengths of the tool. It will be slow and ultimately kind of expensive, PLA / ABS are at least $10 per kilo.
This is not a knock on 3D printing... MDF just happens to be a really excellent material for speaker cabinets. Cheap, fairly inert, fairly stiff, fairly dense, fairly easy to work with... hard to beat.
However, I think making a hollow cabinet and filling it with sand and/or concrete could be really effective and pretty efficient, and would outclass MDF.
I am likewise excited by the possibilities for DIY. I think the title illustrates the most interesting thing about 3D printing. "Impossible" designs for conventional building techniques.
Most of the examples in this thread are possibly challenging, but by no means impossible to build conventionally. I want to see spheroid / teardrop shapes, multi-layer cabinet walls, things like that. Making 3 layers of sand, concrete, and sand inside a 3D printed housing is not really a big deal once you do the design. Not even remotely worth the effort for an MDF box, but if you're printing it, well, the construction is not the hard part. Even doing a CLD layer by filling it with green glue ... the hard part is pouring the glue.
Aside from that, Augerpro's work is really impressive and helpful to the scene and on DIYAudio you also have the user Patrickbateman who has done a lot of printed enclosures and other parts.
Post processing and finishing is a real job, but of course that's equally true of any wooden enclosure. For 3D prints I like to coat it with filler of some kind (wood, bondo, etc) then sand, paint, sand, paint until satisfactory results are achieved. Not difficult, just a little time-consuming.
Lastly, I don't really consider the size of the printer to be a true limitation, you just need a lot of patience and the willingness to glue several parts together.
(The current state of
my 3D printed QRD project)