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Is COVID strategy moving towards herd-immunity?!

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North_Sky

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When was the last time the world was in a similar situation as we are now in?
...1918? Did they have lockdowns then, and the economy was doing just fine with Amazon, Apple, IBM, Microsoft, Facebook, Twitter, Tesla, Moderna, Kodak, Starbucks, ...?

Wearing masks was obligatory in some regions, like San Francisco for example?

Ok, this one won't reach 50-100 million deaths, but what if it reaches three times where we are now...like 2 million deaths? Is that a reasonable figure worldwide for the next couple years? What if suddenly the economy falters and affects the poverty worldwide, and more children die consequently? Are the rich people, billionaires are going to save the children? Who then? WHO?

Herd immunity? ...In twenty years from now?

Oh I know, a vaccine of course. God lock.
 

Racheski

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Racheski

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It seems like this article (the Oxford one) needs a point by point rebuttal. The latter 2 appear to be opinions that there are better models for the epidemiology of the Corona virus.

My first objection is the misleading title of the article. We have NOT reached herd immunity except possibly in some particularly hard hit areas in NYC, Italy and Spain at the cost of thousand of deaths and a significant percentage of survivors with long term disabilities such as lung damage, kidney and heart damage, and 'brain fog'. In this view a better comparison may not be the seasonal flu, but rather polio which both killed and paralyzed albeit in greater numbers than Covid.

The first question to her from Alastair Benn In the debate over T-cell immunity or cross-reactivity with coronaviruses, the common-sense view is that exposure to things that are similar does give you some protection, and it seems to be borne out in recent studies.

When I see the the words 'common-sense' a red flag goes up. It's common sense that the earth is flat. He doesn't reference the 'recent studies'. Finally a google search on Alistair shows him as author of another article Mandatory masks are an insult to our intelligence. This puts him at odds with the vast majority of the scientific community which has repeatedly shown that mask wearing as an effective method of reducing exposure and transmission of the corona virus.

She talks about how the mortality rate is lower than was 'expected' from a novel virus because of varying degrees of immune response due to other corona viruses. The problem I have with this is 17.5 million cases and 680,000 deaths so far (translates to about 0.4% mortality) with no end in sight until we have vaccines and/or treatments. It's all very nice for a theoretical epidemiologist to say that deaths are a lower percentage than expected. She might have a different reaction if one of her family died from it or god forbid her.

the 2nd question is from Mutaz Ahmed : When the serological studies were conducted a couple of months ago, antibody rates were very low in the UK. Is that because people weren’t vulnerable to infection, or because once they were infected they had some level of innate immunity?

She refers to studies (unreferenced) that indicate "that slums of Buenos Aires, which reports a 50% seroprevalence. And there have been studies from Lodi, Italy, where it is I think 60%" and goes on to say that while there is uncertainty in these studies that "I think very few people would agree that exposure rates in London are less than 20%" again unreferenced. She then leaps to the conclusion that

"The picture that we’re getting is heterogeneous. But even in hotspots, apart from a few reports, they’re still quite low. So why is that?
One reason might be that lockdown stopped the spread of infection, so it was halted at a stage when, say, 20% of people were immune and the rest of the people were still susceptible to infection. Well, under those circumstances, the easing of lockdown should result in fairly rapid growth of cases. And that’s not something we’re seeing."

A different conclusion might be that after the initial lockdown people wore masks and tried to maintain social distancing and in general were cautious about reducing exposure.

It will probably take too long to dissect piece by piece but here are some other 'highlights'.

"The fifth piece of this jigsaw could be that there is some seasonality. I suspect that in the winter it will probably come back, but hopefully only to the regions where it was kept from going by lockdown, and where the seroprevalence levels are genuinely extremely low. "

We don't seem to have seasonality in the US, where currently the worst outbreaks are in the southern states. If there is seasonality, it may have more to do with the fact that in areas with cold winters people stay indoors where transmission occurs more easily, while in areas with very hot summers people stay indoors to stay cool also facilitating transmission.

Alastair: It’s interesting that you mentioned folklore. In the West we have this idea that we want to eliminate disease ..... In some parts of Asia there is a very different approach, it’s more about accommodating yourself to the natural world, and cultivating a more holistic view of how you live with disaster. ....

"Maybe it has something to do with coming from an eastern tradition, but I’d like to think it’s strange because we live with infectious diseases. We do accommodate infectious diseases into our social contract, really. We know that this is a threat we have to deal with."

It is out of context, but the 'eastern traditions' of China (including Taiwan and Hong Kong), Korea and Japan have indeed accommodated infectious diseases into their social contract by wearing masks even before Covid and intensively testing and contact tracing.

Alastair: So you think that the New Zealand approach, eradicating the virus, is both functionally silly and also immoral?

"Well, I don’t know whether I’d go so far as to say it’s immoral. It seems to be very short-sighted, how can it possibly keep the virus out?

I think the smugness, the self-congratulation with which it’s presented is misplaced. The self-righteous attitude is completely ridiculous. If it turns out that the rest of the world, through herd immunity or vaccination, manages to reduce the risk of infection, then what New Zealand will have done would be tantamount to not vaccinating your own child. Just waiting for everyone else to vaccinate their children and then go “ok it’s all safe now."

I frankly don't even understand her response. It's ridiculous to minimize deaths while the world comes up with a vaccine. I guess is her essential point that let the virus ravage. We'll get herd immunity sooner or later, and meantime let the unlucky ones die (note the polio example I gave for some of the survivors) or isolate the high risk from everybody else indefinitely (also called involuntary confinement) or at least until there's a vaccine or herd immunity.

I notice that she never advocates for reducing exposure by social distancing, mask wearing or contact tracing. In fact she says "I’m 55 years old, there’s some slight risk out there. But I would be willing to take that, just as I do with the flu. There’s a risk I might die of flu, but I’m willing to take that risk, because I know that if I don’t then flu will appear as it did before, it will enter the population of immunologically naive individuals, and then there will be a high risk of infection which will have a disproportionate effect on the vulnerable sector of the population. "

What I get is that its patriotic or noble to allow yourself to get sick and possibly die because they're ain't nothing you can do about it, a view maybe more suited to the 18th or 19th century than the 21st where we've already successfully suppressed many deadly epidemic diseases. It may be our hubris to think that we think that we can extend life and conquer diseases, but it is what makes us human IMO.

The article also talks about LOCKDOWN where now there are very few areas which are still in full lockdown. This is the problem with this viewpoint. It was never about lockdown until there's a cure or vaccine. It was always about opening up while minimizing risk.

I may have rambled on too long, but hope that I've pointed out some of the flaws in the article. Thanks for reading this.
If you go to the actual article there is a disclaimer:
"This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice."
That says it all for me.
https://www.medrxiv.org/content/10.1101/2020.07.15.20154294v1
 

scott wurcer

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When was the last time the world was in a similar situation as we are now in?

I talked to my 96 yr. old mother a couple of weeks ago, when things like polio came around the local health officials came by and slapped a quarantine notice on your door. Virtually no one even thought of not complying, frankly we were politically far to the right in those days something has changed.
 

boswell

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play God, not me, not wealthy enough to play at god for even 5 minutes, not even 5 nanoseconds actually, btw the super mega rich are as vocal as ever at the moment,
also not sure to which god you're referring to as the "G" wasn't capitalized
personally I think that some of those Egyptian gods were (or is it are) pretty cool, maybe Horus, I did enjoy Stargate though
 

Phorize

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Just a thought, and one that is only informed from my own involvement in social policy during this pandemic , listening to epidemiology specialists from Johns Hopkins and similar, and a few economists. However non-trivial the impact and ultimate outcome of this disease is, the issue isn’t really COViD 19. The view of the scientific community is that a pandemic involving a disease that is perfectly optimised to a) kill the maximal number of people that contract it and b) be maximally communicable is almost inevitable-we are talking about prospective diseases that would very much pose a threat to the survival of humans as a species. I live in the uk, which has been exposed as lacking the political/governmental, administrative, macro economic and civil societial means to mitigate COVID 19 to any real extent-we should realise that both the US and UK governments were happy to give this disease a free run until very recently, and implemented this policy without factoring for the science on the subject, or making basic preparations for the economic impact. There was no strategy and a heavy price will be paid in mortality, morbidity, economically and socially; it may even be looked back on as the straw that broke the constitutional camels back in the UK-we’ll see. This doubtless applies in some other countries, but I highlight the US and the UK as they have failed more conspicuously in this area on objective grounds when factoring for their actual capacity to mobilise resources relative to other less developed nations. Obviously we failed this test miserably, and in a way that certainly indicates non-survival of something more serious. Of course, to be able to survive this perfect outbreak we must first survive climate change and possibly more immediately, the phenomenon of majority unemployment in a highly automated economy. Fortunately for us these issues can all be factored for in a single programme of economic adaptation. Unfortunately though there isn’t much happening in the political or economic culture to indicate that the response will be anything other that after the event.
 
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lashto

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I have a feeling that no vaccine is effective, neither any herd immunity. This virus is like a cold virus, only much deadlier. You can get reinfected again and again until it kills you, if not now, in a decade or so, when you're immune system gets weakened as you age. I think this virus will wipe out 50% of the earth's population within a couple of decades. Maybe, we as humans don't deserve to live... This is what happens when humans abuse animals for food...
I'd say that 50% of population is a pretty wild exaggeration. OTOH, you do have a good point and we might be way too optimistic about those vaccines. The Covid virus seems to be similar to cold/flu and after ~100 years of trying, our flu-vaccines are nowhere near winning the battle. Plus, if the best Covid vaccine is too expensive, it could do a lot more harm than good.

What if we have to live with this thing for many, many years to come (or even 'forever')?! Whether we like it or not, whatever herd-immunity can be achieved is probably the only solution in that case.
 

boswell

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play God, not me, not wealthy enough to play at god for even 5 minutes, not even 5 nanoseconds actually, btw the super mega rich are as vocal as ever at the moment,
also not sure to which god you're referring to as the "G" wasn't capitalized
personally I think that some of those Egyptian gods were (or is it are) pretty cool, maybe Horus, I did enjoy Stargate though
 

boswell

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OTTOMH (dont you love acronyms)
99% of current population will die in the next 10 decades at least
common cold is not a single virus but a name attributed to about 16 rhino-virii that have similar but also different symptoms mainly mild, they mutate but have stayed harmless, no vaccine has been developed for colds.
influenza virus mutates and has about 4 major strains, for which an effective(60-70%+) vaccine is constantly created/modified regularly(biannually for the two hemispheres) and is not an aggressive spreader but very deadly when there are clusters
 

Tks

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Heard immunity possibly won't work, in the same way it doesn't work for the Flu unless you take vaccines that have predicted properly the variant of the strain and it's bi-annual mutation sort.

Corona virus(s) immunity seems to only last around a few months to two years at best for the existing strains we have some data for. Obviously we don't know how C-19 will be, nor how effective various vaccines might be. People's response by way of symptom manifestation seems to vary quite a bit, and depending on such, the antibody concentrations also vary heavily.

Some reading on a few preliminary observations. And Florian Kramer who concludes a pretty liberal take on immunity lasting 1-3 years.

Lots more observations need to be done. But this virus is seemingly going to be an issue for a while unfortunately.
 

Thomas_A

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Heard immunity possibly won't work, in the same way it doesn't work for the Flu unless you take vaccines that have predicted properly the variant of the strain and it's bi-annual mutation sort.

Corona virus(s) immunity seems to only last around a few months to two years at best for the existing strains we have some data for. Obviously we don't know how C-19 will be, nor how effective various vaccines might be. People's response by way of symptom manifestation seems to vary quite a bit, and depending on such, the antibody concentrations also vary heavily.

Some reading on a few preliminary observations. And Florian Kramer who concludes a pretty liberal take on immunity lasting 1-3 years.

Lots more observations need to be done. But this virus is seemingly going to be an issue for a while unfortunately.

There will be no absolute herd immunity to eliminate the virus. What immunity will do is to reduce R0, but a steady state of the R0 will not occur until a couple of years have passed. When the immunity wanes, you are susceptible again. But reinfections will probably be milder, as seen for other endemic coronavirus.
 

North_Sky

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Herd immunity can't be a workable solution.
If it was a solid strategy we would keep our schools open, our bars open, our restaurants open, our movie theaters open, our museums, our shopping malls, our grocery stores, our gas stations, our borders, our airplanes, our airports, our subways, Disneyland,...everything normal open as usual.
That would be a death sentence to our elders...me and you.

Is that a good strategy, or what would that be?

Everyday I wake up and for the last month (July) I see from 200,000 to 300,000 new infected cases a day, worldwide. Since the 1st of April (4 months now) I see 5,000 deaths average a day, worldwide. Tomorrow I don't have the same dream as I had before January 1st, 2020. It's like not having control on our destiny the same as before in the other life...prior in the year 2019 and since December 1920.

Herd immunity is not China's, Singapore's, Australia's, North Korea's, South Korea's, Japan's, Germany's, Canada's, Norway's, Ireland's, Iceland's, New Zealand's .... strategy.
Herd immunity is not most countries' strategy...zero plan.
 

Phorize

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Thomas_A

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North_Sky

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Yeah, let it die a slow death and we'll come back in ten years just for the fun of it...to see how many infected and dead. I bet 10%+ of us won't be here to see the day ...
 

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