It's a loaded topic, and I haven't built/heard/tried everthing I want to, but here are some random thoughts
-I would first look at the nature and size of the room, and the nominal listening distance or distances in that room and work from there.
-Speakers with a narrow pattern such as this one really shine in larger rooms, to increase the direct to reflected sound ratio. I recently built some 15" coaxial full (ish) range (40hz -3dB) main monitors for a large studio room and especially in stereo this (and other) type of narrow directivity speakers can make other loudspeakers sound like toys under the right circumstances. Give them too little space and then things become less enjoyable as sounds are easily identified as coming from the left and right with an extremely clear phantom image (headhone effect). There's always a sweetspot when it comes to the ratio of direct/reflected sound.
-Keeping the beamwidth controlled (constant or steadily increasing) down to the transition frequency is never detrimental to the sound.
-There is no such thing as too neutral, yet at the same time some flaws don't bother us and aren't even noticeable until we do a proper a/b test with another speaker that doesn't feature such a flaw.
-The estimated in-room response does not predict the perceived in-room response, rather the measured response. I have tested quite different crossovers on R2 for example and in my room at least, I'm not sure I can seperate them with absolute certainty, despite the different in-room response (both estimated and measured). This because the direct sound is identical and the off-axis responses, while different, are both 'controlled'. Differences might become more obvious in different rooms or with different listening distances, this is one thing I have not been able to test yet.
-Bass matters a lot.